C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 39/17 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2405319
Compositions and methods are provided for identifying and designing modulators of integrin-mediated cell-cell interactions through altering the interaction of ADAM 23 with .alpha.v.beta.3 integrin. Compositions and methods are also provided for modulating integrin-mediated cell-cell interactions such as those involved in angiogenesis, induction of active metalloproteinases, tumor progression and neural tissue growth.
La présente invention concerne des compositions et des techniques permettant d'identifier et d'étudier des modulateurs des interactions de cellule à cellule induites par l'intégrine par la modification des interactions de ADAM 23 avec l'intégrine .alpha.alphav.beta.beta3. Cette invention concerne aussi des compositions et des techniques permettant de moduler des interactions de cellule à cellule induites par l'intégrine telles que celles en cause dans l'angiogenèse, l'induction de métalloprotéinases actives, la progression tumorale et la croissance de tissus nerveux.
Bianchi Albert Bernard
Freije Jose Maria Perez
Garcia Jose Manuel Lopez
Lopez-Otin Carlos
Miguel Santiago Cal
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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