C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07K 14/00 (2006.01) C07K 14/505 (2006.01) C12N 9/00 (2006.01) C12N 15/67 (2006.01) C12P 13/00 (2006.01) C12P 13/04 (2006.01) C12P 13/22 (2006.01) C12P 19/26 (2006.01) C12P 21/02 (2006.01) C12Q 1/04 (2006.01)
Patent
CA 2444098
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
L'invention concerne des compositions et des procédés permettant de générer des composants du mécanisme biosynthétique protéinique comprenant des synthétases orthogonales tRNA et orthogonales aminoacyl-tRNA, ainsi que des paires orthogonales de synthétases tRNA. L'invention concerne également des procédés d'identification desdites paires orthogonales. Ces composants peuvent être utilisés pour incorporer des aminoacides non naturels dans des protéines in vivo.
Anderson John Christopher
Chin Jason W.
Liu David R.
Magliery Thomas J.
Meggers Eric L.
Fetherstonhaugh & Co.
The Regents Of The University Of California
The Scripps Research Institute
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