C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01)
Patent
CA 2558050
The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo- obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
Compositions et méthodes associées pour traiter le syndrome du colon irritable (IBS) et d'autres troubles et états pathologiques gastro-intestinaux (par ex. les troubles du transit gastro-intestinal, les troubles gastro-intestinaux fonctionnels, le reflux gastro-oesophagien pathologique, le reflux duodénogastrique, la maladie de Crohn, la rectocolite hémorragique, les maladies inflammatoires du tube digestif, les brûlures gastriques fonctionnelles, la dyspepsie (y compris la dyspepsie fonctionnelle ou dyspepsie non ulcéreuse), la gastroparésie, la pseudo-obstruction intestinale chronique (ou pseudo-obstruction colique), et des troubles et états pathologiques associés à la constipation, par ex. la constipation associée à l'utilisation d'analgésiques opiacés, la constipation post-chirurgicale (l'iléus post-opératoire) et la constipation associée à des troubles neuropathiques, ainsi que d'autres troubles et états pathologiques utilisant des peptides et d'autres agents qui activent le récepteur guanylate cyclase C (GC-C).
Currie Mark G.
Fretzen Angelika
Kurtz Caroline
Mahajan-Miklos Shalina
Milne G. Todd
Ironwood Pharmaceuticals Inc.
Microbia Inc.
Smart & Biggar
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