Methods and compositions for treating and preventing malaria

Details Methods and compositions for treating and preventing malaria Methods and compositions for treating and preventing malaria

C - Chemistry, Metallurgy

07

K

C07K 14/445 (2006.01) A61K 39/015 (2006.01) A61P 33/06 (2006.01) G01N 33/569 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2610100

Vaccines, in particular, antigens capable of eliciting antibodies capable of preventing invasion of Plasmodium parasite into erythrocytes, and use of said vaccines for the treatment and/or prevention of malaria. In one embodiment, the antigen is an immunogenic molecule comprising a contiguous amino acid sequence of a reticulocyte--binding protein homologue (Rh) of a strain of Plasmodium falciparum, wherein when administered to a subject the molecule is capable of inducing an invasion- inhibitory immune response to the strain. Also disclosed is a method of screening for the presence of a Plasmodium falciparum invasion-inhibitory antibody directed against a reticulocyte-binding homologue protein (Rh) of a strain of Plasmodium falciparum in a subject.

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