A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2716628
Described herein are methods for treating or preventing atherosclerosis by inhibiting the activation or binding of macrophage migration inhibitory factor to CXCR2 and CXCR4. Such inhibition is achieved by administration of either a single agent or a combination of agents. Also described herein are agents that inhibit MIF-binding or MIF--activation of CXCR2 or CXCR4. Further described are pharmaceutical compositions comprising such agents and their use for treating or preventing atherosclerosis.
La présente invention concerne des procédés destinés au traitement ou à la prévention de l'athérosclérose en inhibant l'activation ou la liaison du facteur inhibiteur de migration des macrophages ou "MIF" (Macrophage Migration Inhibitory Factor) sur CXCR2 et CXCR4. Pour réaliser cette inhibition, l'invention propose d'administrer soit un agent seul, soit une combinaison d'agents. L'invention concerne également des agents qui inhibent la liaison du MIF ou l'activation du MIF de CXCR2 ou CXCR4. L'invention concerne en outre des compositions pharmaceutiques comprenant de tels agents, et leur utilisation pour le traitement ou la prévention de l'athérosclérose.
Bernhagen Juergen
Weber Christian
Zernecke Alma
Carolus Therapeutics Inc.
Gowling Lafleur Henderson Llp
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