Methods and compositions including a 13 kd b. burgdorferi...

Details Methods and compositions including a 13 kd b. burgdorferi... Methods and compositions including a 13 kd b. burgdorferi...

C - Chemistry, Metallurgy

07

K

C07K 14/20 (2006.01) A61K 38/16 (2006.01) A61K 39/02 (2006.01) C07K 16/12 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2193682

A 13 kD protein from Borrelia burgdorferi is disclosed. The 13 kD protein has been characterized in mutants of B. burgdorferi which lack the major outer surface proteins (Osp) A, B, C, and D. The invention also includes methods for detecting antibodies to B. burgdorferi and methods of generating an immune response using the 13 kD protein.

L'invention se rapporte à une protéine de 13 kD provenant de Borrelia burgdorferi. Cette protéine de 13 kD a été caractérisée dans des mutants de B. burgdorferi auxquels il manque les principales protéines de surface externe (Osp) A, B, C et D. L'invention se rapporte également à des procédés de détection d'anticorps dirigés contre B. burgdorferi, ainsi qu'à des procédés de production d'une réponse immunitaire au moyen de la protéine de 13 kD.

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