Methods and compositions to inhibit p2x7 receptor expression

Details Methods and compositions to inhibit p2x7 receptor expression Methods and compositions to inhibit p2x7 receptor expression

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2594672

Methods and compositions for the downregulation of P2X7 receptor expression or activity are disclosed. Preferred compositions comprise siNA. The methods and compositions are useful in the treatment of diseases characterised by increased P2X7 receptor activity, such as neuronal degeneration, Alzheimer~s disease, inflammatory diseases, and some cancers.

L'invention concerne des procédés et des compositions destinés à la régulation négative de l'expression ou de l'activité du récepteur P2X7. Les compositions préférées comprennent siNA. Les procédés et les compositions sont utiles dans le traitement de maladies caractérisées par une activité accrue du récepteur P2X7, telle que la dégénération neuronale, la maladie d'Alzheimer, des maladies inflammatoires et certains cancers.

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