A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/34 (2006.01) A61K 35/26 (2006.01) A61K 35/28 (2006.01) A61K 35/50 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2479309
The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering lymphoid cells such as natural killer (NK) cells activated with interleukin-2 (IL-2), lymphokine-activated killer (LAK) cells and/or tumor-infiltrating lymphocytes (TILs) and/or cytotoxic lymphocytes (CTLs), or stem cells such as those derived from the bone marrow or from umbilical cord tissue. The methods are also useful for targeting a gene of interest to a tissue in a mammal by introducing a cell containing the gene of interest and administering a glycoconjugate to the mammal.
La présente invention se rapporte à des méthodes destinées à fournir des cellules à un tissu cible de mammifère, lesdites méthodes faisant appel à un glycoconjugué permettant d'acheminer la cellule jusqu'à un organe désiré dudit mammifère. Les procédés selon l'invention conviennent tout particulièrement à l'administration de cellules lymphoïdes telles que des cellules tueuses naturelles (NK) activées par l'interleukine-2 (IL-2), des cellules tueuses activées par les lymphokines (LAK), et/ou des lymphocytes infiltrant les tumeurs (TIL), et/ou des lymphocytes cytotoxiques (CTL), ou des cellules souches telles celles dérivées de la moelle osseuse ou d'un tissu de cordon ombilical. Les méthodes selon l'invention permettent également de fournir un gène d'intérêt à un tissu de mammifère, par l'introduction d'une cellule contenant le gène d'intérêt et par l'administration d'un glycoconjugué au mammifère.
Marks & Clerk
U.s. Government Represented By The Department Of Veterans Affair
LandOfFree
Methods and compositions using cellular asialodeterminants... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions using cellular asialodeterminants..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions using cellular asialodeterminants... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1383190