A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/404 (2006.01) A61K 31/55 (2006.01) A61P 25/16 (2006.01) C12N 5/10 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2617601
Induction of neuronal fate in neural stem cells or neural progenitor or precursor cells, or other stem cells, and enhancement of induction of a specific neuronal phenotype, and particularly to induction and enhancement of induction of a midbrain dopaminergic neuronal phenotype. Expressing a nuclear receptor of the Nurr1 subfamily above basal levels within the cell, and regulating GSK-3~ inhibition within the cell other than by means of a ligand for a Frizzled receptor.
Cette invention concerne l'induction d'une destinée neuronal dans des cellules souches neurales ou dans des cellules progénitrices ou précurseurs, ou dans d'autres cellules souches, et l'accentuation de l'induction d'un phénotype neuronal spécifique,, singulièrement l'induction et l'accentuation de l'induction du phénotype neuronal dapaminergique du mésencéphale. L'invention concerne également l'expression d'un récepteur nucléaire de la sous-famille Nurr1 au dessus de niveaux basiques et la régulation de l'inhibition de GSK-3ß à l'intérieur de la cellule au sein de la cellule par des moyens autres qu'un récepteur Frizzled.
Arenas Cases Ernesto A.
Castelo Branco Goncalo
Rawal Nina
Arenas Cases Ernesto A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Castelo Branco Goncalo
Neuro Therapeutics Ab
Rawal Nina
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