A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/05 (2006.01) A61P 3/04 (2006.01)
Patent
CA 2613141
Provided herein are methods and compositions for treating or preventing metabolic disorders, such as obesity and diabetes. Methods may comprise modulating the activity or level of a sirtuin, such as SIRTl or Sir2. Exemplary methods comprise contacting a cell with a sirtuin activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin, or an inhibitory compound, such as nicotinamide.
L'invention concerne des méthodes et des compositions de traitement ou de prévention de troubles métaboliques, tels que l'obésité et le diabète. Ces méthodes peuvent consister à moduler l'activité ou le niveau d'un composé activant la sirtuine, tel que SIRT1 ou Sir2. Des méthodes exemplaires consistent à mettre en contact une cellule avec un composé activant la sirtuine, tel qu'une flavone, un stilbène, une flavanone, une isoflavone, une catéchine, une chalcone, un tannin ou une anthocyanidine, ou un composé inhibiteur, tel que la nicotinamide.
Argmann Carmen
Auwerx Johan
Dipp Michelle
Lagouge Marie
Milburn Michael
Borden Ladner Gervais Llp
Sirtris Pharmaceuticals Inc.
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