Methods, devices, and compositions for lysis of occlusive...

Details Methods, devices, and compositions for lysis of occlusive... Methods, devices, and compositions for lysis of occlusive...

C - Chemistry, Metallurgy

12

N

C12N 9/72 (2006.01) A61K 38/17 (2006.01) A61K 38/49 (2006.01) A61L 29/16 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) C07H 21/04 (2006.01) C12N 9/64 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2426115

Various mutant forms of pro-urokinase ("pro-UK") perform in the manner of pro-UK in lysing "bad" blood clots (those clots that occlude blood vessels), while sparing hemostatic fibrin in the so-called "good" blood clots (those clots that seal wounds, e.g., after surgery or other tissue injury). Thus, these pro-UK mutants are excellent and safe thrombolytic agents. These advantages allow them to be used in a variety of new methods, devices, and compositions useful for thrombolysis and treating various cardiovascular disorders in clinical situations where administration of other known thrombolytic agents has been too risky or even contraindicated.

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