Methods for blocking the interaction between nkp80 and its...

Details Methods for blocking the interaction between nkp80 and its... Methods for blocking the interaction between nkp80 and its...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2661923

The present invention relates to applications based on the findings of the interaction between NKp80 and its ligand AICL. The use of substances blocking the interaction between NKp80 and AICL is disclosed, for the manufacture of a medicament for the prevention or treatment of inflammatory diseases, in particular autoimmune diseases. Preferably, the substance is selected from the group comprising anti-NKp80- antibodies, anti-AICL-antibodies, soluble NKp80, soluble AICL, or functional fragments thereof.

La présente invention concerne des applications basées sur les découvertes de l'interaction entre NKp80 et son ligand AICL. L'utilisation de substances bloquant l'interaction entre NKp80 et AICL est décrite, pour la fabrication d'un médicament servant à la prévention ou au traitement de maladies inflammatoires, en particulier de maladies auto-immunes. De préférence, la substance est choisie dans le groupe constitué par des anticorps anti-NKp80, des anticorps anti-AICL, du NKp80 soluble, du AICL soluble ou des fragments fonctionnels de ceux-ci.

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