C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2366237
The present invention is directed to methods and compositions for use in screening nucleic acid populations for nucleic acid polymorphisms. The methods, referred to generally as ValiGene?SM~ Mutation Screening, Peptide- Linked (VGMS-PL) methods, are specifically designed for high-throughput genotype mapping and gene expression analysis of animal and plant nucleic acids without requiring a PCR amplification step. In particular, the methods of the invention utilize oligonucleotide probes labeled with distinguishable and identifiable peptide tags, that are captured on addressable antibody arrays.
La présente invention concerne des méthodes et des compositions utilisées pour le criblage de polymorphismes d'acides nucléiques dans des populations d'acides nucléiques. Ces méthodes, dénommées <u>V</u>ali<u>G</u>ene<SM> <u>M</u>utation <u>S</u>creening, <u>P</u>eptide-<u>L</u>inked (VGMS-PL) sont tout spécialement conçues pour la cartographie à fort rendement du génotype et l'analyse de l'expression des gènes d'acides nucléiques animaux et végétaux sans opération préalable d'amplification par la polymérase. En particulier, les méthodes selon l'invention font intervenir des sondes oligonucléotidiques marquées par des étiquettes peptidiques repérables et identifiables fixées sur des batteries d'anticorps adressables.
Iris Francois J. M.
Pourny Jean-Louis
Treich Isabelle
Sim & Mcburney
Valigen (us) Inc.
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