G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/542 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01) G01N 33/86 (2006.01)
Patent
CA 2740904
The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water- soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
La présente invention concerne le développement de systèmes dessai in vitro qui provoquent la libération dun polymère hydrosoluble, tel que le polyéthylèneglycol (PEG) et lacide polysialique (PSA), à partir de protéines modifiées avec un polymère hydrosoluble lié de manière réversible. Linvention concerne des procédés pour analyser la libération du polymère hydrosoluble et mesurer lactivité de protéine rétablie. Linvention comprend en outre des procédés appropriés pour le contrôle qualité de protéines modifiées avec des polymères hydrosolubles libérables, comprenant des polymères tels que PEG et PSA.
Anderle Heinz
Bossard Mary J.
Culbertson Sean M.
Fang Zhihao
Rottensteiner Hanspeter
Baxter Healthcare S.a.
Baxter International Inc.
Nektar Therapeutics
Sim & Mcburney
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