Methods for enhanced propagation of cells

Details Methods for enhanced propagation of cells Methods for enhanced propagation of cells

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/23 (2006.01) A61P 13/00 (2006.01)

Patent

CA 2728215

The present invention relates generally to methods for the isolation and propagation of cells. For example, embodi-ments of the present invention relate to isolation and propagation methods for the manufacture of a large number of cells for use, for example, in biotherapeutic devices, such as devices for renal replacement therapy for the treatment of acute renal failure (ARF), acute tubular necrosis (ATN), multi-organ failure (MOF), sepsis, cardiorenal syndrome (CRS) and end-stage renal disease (ESRD).

La présente invention porte d'une manière générale sur des procédés permettant l'isolement et la propagation de cellules. Par exemple, les modes de réalisation de la présente invention portent sur des procédés d'isolement et de propagation destinés à la fabrication d'un grand nombre de cellules en vue d'une utilisation, par exemple, dans des dispositifs biothérapeutiques tels que des dispositifs de thérapie de substitution rénale pour le traitement d'une insuffisance rénale aiguë (ARF), d'une nécrose tubulaire aiguë (ATN), d'une défaillance multiviscérale (MOF), d'une sepsie, d'un syndrome cardiorénal (CRS) et d'une maladie rénale au stade terminal (ESRD).

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