C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G06F 17/18 (2006.01)
Patent
CA 2478605
The present invention provides multivariate methods for identifying differentially expressed genes based on microarray expression data. An improved random search procedure involving certain probability distances is provided. The methods of this invention implement a successive elimination procedure to remove smaller subsets resulted from each step of the random search thereby establishing a larger set of differentially expressed genes.
L'invention concerne des procédés à variables multiples permettant d'identifier des gènes exprimés de manière différentielle en fonction de données d'expression de microréseau. L'invention concerne également une procédure de recherche aléatoire améliorée mettant en oeuvre certaines distances de probabilité. Les procédés selon l'invention mettent en oeuvre une procédure d'élimination successive permettant d'éliminer des sous-ensembles plus restreints de chaque étape de la recherche aléatoire, établissant ainsi un ensemble plus conséquent de gènes exprimés de manière différentielle.
Boucher Kenneth
Jones David
Klebanov Lev
Szabo Aniko
Tsodikov Alexander
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Utah Research Foundation
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