Methods for inhibiting protein kinases

Details Methods for inhibiting protein kinases Methods for inhibiting protein kinases

A - Human Necessities

61

K

A61K 31/4985 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2628534

The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.

La présente invention concerne des méthodes d'inhibition de protéine kinases sélectionnées au sein du groupe constitué par l~AKT, la checkpoint kinase, la kinase Aurora, la kinase Pim-1 et la tyrosine kinase, par l'emploi de composés de type imidazo[1,2-a]pyrazine. La présente invention concerne également des méthodes de traitement, de prévention, d'inhibition ou de soulagement d'une ou de plusieurs maladies associées à des protéine kinases par l'utilisation de tels composés.

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