C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/56 (2006.01) A61K 31/513 (2006.01) A61P 31/18 (2006.01) C07D 239/47 (2006.01) C07D 239/52 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2428753
A method for inhibiting sexual transmission of HIV comprising topically applying to the skin or epithelial tissue of a human a composition comprising a non-nucleoside reverse transcriptase inhibitor ("NNRTI")that is able to inhibit viral replication for periods exceeding 12, 24, or even 36 days, at concentrations below even 10 uM. In one embodiment the NNRTI is a dihydro- alkyloxy-benzyl-oxopyrimidine (DABO).
L'invention concerne un procédé d'inhibition de la transmission sexuelle du VIH, consistant à appliquer topiquement sur la peau ou sur un tissu épithélial d'un humain une composition comportant un inhibiteur non nucléosidique de la transcriptase inverse (INNTI) qui peut inhiber la réplication virale durant des périodes supérieures à 12, 24 ou même 36 jours, à des concentrations inférieures même à 10 uM. Dans un mode de réalisation, l'INNTI est une dihydro-alkyloxy-benzyl-oxopyrimidine (DABO).
Artico Marino
Bryant Martin L.
La Colla Paolo
Sommadossi Jean-Pierre
Idenix (cayman) Limited
Mbm Intellectual Property Law Llp
Universita Degli Studi Di Cagliari
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