Methods for making apo-2 ligand using divalent metal ions

Details Methods for making apo-2 ligand using divalent metal ions Methods for making apo-2 ligand using divalent metal ions

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 47/02 (2006.01) C07K 14/705 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2377585

Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.

L'invention concerne des méthodes de fabrication de ligands Apo-2 et de formulation de ligands Apo-2, à l'aide d'ions métalliques divalents. Ces ions métalliques divalents comprennent du zinc et du cobalt, ce qui améliore la formation et la stabilité des trimères du ligand Apo-2. L'invention concerne également la structure cristalline du ligand Apo-2, ainsi que des polypeptides variants du ligand Apo-2 identifiés par mutagénèse dirigée à l'aide d'un oligonucléotide.

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