Methods for preventing mitochondrial permeability transition

Details Methods for preventing mitochondrial permeability transition Methods for preventing mitochondrial permeability transition

A - Human Necessities

61

K

A61K 38/03 (2006.01) A61K 38/07 (2006.01) C07K 5/00 (2006.01) C07K 5/10 (2006.01) C07K 5/11 (2006.01)

Patent

CA 2515080

The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r + 1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt + 1, except that when a is 1, pt may also be 1.

L'invention porte sur une méthode de prévention et réduction de la transition de la perméabilité mitochondriale. La méthode consiste à administrer une dose efficace d'un peptide aromatique cationique présentant au moins une charge positive nette; comportant un minimum de 4 acides aminés et un maximum d'environ 20 acides aminés; et satisfaisant: à la relation entre le nombre minimum de charges positives nettes (p¿m?) et le nombre total (r) des résidus d'acides aminés, selon laquelle 3p¿m? est le plus grand nombre inférieur ou égal à r + 1; et à la relation entre le nombre minimum de groupes aromatiques (a) et le nombre total des charges positives nettes (p¿t?), selon laquelle 2a est le plus grand nombre inférieur ou égal à (p¿t?) + 1, sous réserve que si a est 1 p¿t? puisse également être 1.

Affiliated with

Also associated with

Rating

Methods for preventing mitochondrial permeability transition does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for preventing mitochondrial permeability transition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for preventing mitochondrial permeability transition will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1344103