Methods for producing surfaces that resist non-specific...

Details Methods for producing surfaces that resist non-specific... Methods for producing surfaces that resist non-specific...

C - Chemistry, Metallurgy

08

J

C08J 7/04 (2006.01)

Patent

CA 2555398

A method is disclosed herein for treating a polymeric surface to resist non-specific binding of biomolecules and attachment of cells. The method includes the steps of: imparting a charge to the polymeric surface to produce a charged surface; exposing the charged surface to a nitrogen-rich polymer to form a polymerized surface; exposing the polymerized surface to an oxidized polysaccharide to form an aldehyde surface; and exposing the aldehyde surface to a reducing agent. Advantageously, a method is provided which produces surfaces that resist non-specific protein binding and cell attachment and that avoids the use of photochemical reactions or prior art specially designed compounds.

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