Methods for refolding of recombinant antibodies

C - Chemistry – Metallurgy – 12 – P

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C12P 21/06 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2584211

The present invention is generally directed to methods of producing an increase in the enrichment or recovery of preferred forms of IgG proteins. More particularly, the invention relates to subjecting preparations of such recombinant IgG proteins with a reduction/oxidation coupling reagent and optionally a chaotropic agent.

La présente invention concerne des procédés de production d'une augmentation de l'enrichissement ou de la récupération de formes préférées de protéines IgG. L'invention concerne plus particulièrement des préparations de telles protéines recombinantes IgG avec un réactif de couplage réduction/oxydation et éventuellement un agent chaotropique.

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