Methods for stable transduction of cells with viral vectors

Details Methods for stable transduction of cells with viral vectors Methods for stable transduction of cells with viral vectors

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 48/00 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2421063

The present invention provides methods, as well as compositions related thereto, for the efficient transduction of cells using viral vectors. The efficiency of transduction is increased by contacting the cell to be transduced with one or more molecules that bind the cell surface. Contact with a cell surface binding molecule may occur before, after, or simultaneously with contact between the viral vector and the cell. The transduced vectors may be constructed to express a gene of interest, permitting the transduced cells to be used as therapeutic and prophylactic agents.

La présente invention concerne des méthodes, ainsi que des compositions associées, permettant d'obtenir une transduction cellulaire efficace à l'aide de vecteurs viraux. L'efficacité de la transduction augmente par la mise en contact de la cellule à transduire avec une ou plusieurs molécules de liaison à la surface de la cellule. Le contact avec la surface d'une molécule de liaison à la surface de la cellule peut se produire avant, après, ou en même temps qu'un contact entre le vecteur viral et la cellule. Les vecteurs transduits peuvent être construits pour exprimer un gène d'intérêt, permettant aux cellules transduites d'être utilisées comme agents thérapeutiques et prophylactiques.

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