A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/498 (2006.01) A61P 7/00 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2561141
The invention describes methods for treating blood disorders or for treating the symptoms and/or complications associated with blood disorders by administering a therapeutically effective amount of at least one nitric oxide donor compound and optionally at least one antioxidant, or a pharmaceutically acceptable salt thereof, and/or at least one therapeutic agent. The antioxidant is preferably a hydralazine compound or a pharmaceutically acceptable salt thereof. The nitric oxide donor compound is preferably N- hydroxy-L-arginine and/or isosorbide dinitrate and/or isosorbide mononitrate. The blood disorder is preferably sickle cell anemia. The complication resulting from a blood disorder is preferably pulmonary hypertension.
L'invention concerne des méthodes de traitement des troubles sanguins ou de traitement des symptômes et/ou complications associées aux troubles sanguins par administration d'une quantité efficace d'un point de vue thérapeutique d'au moins un composé donneur d'oxyde nitrique et éventuellement d'au moins un antioxydant, ou un sel acceptable d'un point de vue pharmaceutique de celui-ci, et/ou au moins un agent thérapeutique. L'antioxydant est, de préférence, un composé d'hydralazine ou un sel acceptable d'un point de vue pharmaceutique de celui-ci. Le composé donneur d'oxyde nitrique est, de préférence, N-hydroxy-L-arginine et/ou isosorbide dinitrate et/ou isosorbide mononitrate. Le trouble sanguin est, de préférence, l'anémie drépanocytaire. La complication générée par le trouble sanguin est, de préférence, l'hypertension pulmonaire.
Bennett Jones Llp
Nitromed Inc.
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