Methods for treating interleukin-1 mediated diseases

Details Methods for treating interleukin-1 mediated diseases Methods for treating interleukin-1 mediated diseases

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 38/20 (2006.01) C07K 14/545 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2039458

73605-14 Abstract of the Invention Disclosed are medicines for treating interleukin-1 mediated diseases including interleukin-1 mediated arthritis, interleukin-1 mediated inflammatory bowel disease, interleukin-1 mediated septic shock, interleukin-1 mediated ischemia injury, and interleukin-1 mediated reperfusion injury. The medicine com- prises a therapeutically effective amount of an interleukin-1 inhibitor. In a preferred embodiment, the interleukin inhibitor is selected from the group consisting of IL-lraa, IL-lraB, IL-lrax, and a combination thereof. A preferred method of produc- ing IL-lraa, IL-lraB, Il-lrax is by recombinant DNA technology.

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