Methods of enhancing immune induction involving mda-7

Details Methods of enhancing immune induction involving mda-7 Methods of enhancing immune induction involving mda-7

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2477780

The present invention relates to compositions and methods for the enhancing or inducing an immune response against an immunogenic molecule by indirectly activating PKR. More specifically, immunotherapy is improved by co- administering a MDA-7 polypeptide with an immunogenic molecule against which an immune response is desired. Such immunotherapies include cancer vaccines, and compositions thereof are described.

L'invention porte sur des compositions et des procédés permettant d'améliorer ou d'induire une réponse immunitaire contre une molécule immunogène par activation indirecte de PKR. Plus particulièrement, l'immunothérapie est améliorée par co-administration d'un polypeptide MDA-7 avec une molécule immunogène contre laquelle une réponse immunitaire est voulue. Ces immunothérapies comprennent des vaccins contre le cancer, et des compositions correspondantes.

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