Methods of expanding myeloid cell populations and uses thereof

Details Methods of expanding myeloid cell populations and uses thereof Methods of expanding myeloid cell populations and uses thereof

A - Human Necessities

61

K

A61K 35/12 (2006.01) C12N 5/071 (2010.01)

Patent

CA 2585343

The present disclosure relates to a method of expanding myeloid progenitor cells by culturing an initial population of cells in a medium comprising a mixture of cytokines and growth factors that promote growth and expansion of the myeloid progenitor cells. The expanded cell population provides a source of cells as therapeutic treatments for neutropenia and/or thrombocytopenia arising in patients subjected to myeloablative therapy and hematopoietic stem cell transplantation.

L'invention concerne un procédé d'expansion de cellules progénitrices myéloïdes par la mise en culture d'une population initiale de cellules dans un milieu contenant un mélange de cytokines et de facteurs de croissance qui favorisent la croissance et l'expansion de cellules progénitrices myéloïdes. La population de cellules expansées constitue une source de cellules servant d'agents thérapeutiques contre la neutropénie et/ou la thrombocytopénie chez des patients soumis à un traitement myéloablatif et une transplantation de cellules souches hématopoïétiques.

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