A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/10 (2006.01)
Patent
CA 2437864
The present invention provides methods of preventing respiratory infections associated with intubation and/or mechanical ventilation-associated pneumonia, in intubated patients. The method generally involves topical administration of a composition comprising an IB-367 peptide to the oral cavity of an intubated patient. As IB-367 peptides engender very little resistance, a signifiant advantage of the invention is that the prophylactic therapy may be applied without having to worry about creating resistant strains of pathogens.
L'invention concerne des procédés permettant de prévenir des infections respiratoires associées à l'intubation et/ou à la ventilation mécanique, telles que la pneumonie associée à la ventilation, chez des patients intubés. Le procédé consiste de manière générale à administrer par voie topique une composition comprenant un peptide IB-367 dans la cavité buccale d'un patient intubé. Les peptides IB 367 induisant très peu de résistance, un des avantages majeurs de l'invention réside dans le fait que la thérapie prophylactique peut être appliquée sans souci de créer des souches de pathogènes résistants.
Fuchs Henry
Redman Rebecca
Fetherstonhaugh & Co.
Intrabiotics Pharmaceuticals Inc.
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