A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5375 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2616237
The invention relates to compositions and methods for treating nervous disorders. More particularly, the invention relates to methods of treating amyloÊd beta peptide-related disorders, particularly Alzheimer's disease, using Rac1 inhibitors. The invention may be used in mammalian subjects, particularly human subjects, at various stages of the disease, including disease onset. The invention also provides methods of producing, identifying, selecting or optimising compounds for use in the treatment of amyloÊd beta peptide-related disorders, based on a determination of the ability of a test compound to inhibit Rac 1 .
L'invention concerne des compositions et des méthodes pour traiter des troubles nerveux. L'invention concerne plus particulièrement des méthodes de traitement de troubles liés au peptide bêta-amyloïde, notamment la maladie d'Alzheimer, au moyen d'inhibiteurs de Rac1. L'invention peut être appliquée à des sujets mammifères, en particulier des sujets humains, à différents stades de la maladie, notamment au début de la maladie. L'invention concerne également des procédés de production, d'identification, de sélection ou d'optimisation de composés à utiliser dans le traitement de troubles liés au peptide bêta-amyloïde, ces procédés consistant notamment à déterminer l'aptitude d'un composé d'essai à inhiber Rac1.
Beausoleil Eric
Desire Laurent
Leblond Betrand
Picard Virginie
Schweighoffer Fabien
Exonhit Therapeutics Sa
Robic
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