Methods of unfolding proteins using metal complexes

Details Methods of unfolding proteins using metal complexes Methods of unfolding proteins using metal complexes

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) C07K 1/113 (2006.01) C07K 14/005 (2006.01) C07K 14/805 (2006.01)

Patent

CA 2297362

The invention relates to methods of unfolding proteins using metal complexes, particularly cobalt-containing Schiff's base compounds. The proteins can be viral proteins or myoglobin, and the unfolding can be irreversible under physiological conditions. The unfolded proteins exhibit UV/vis absorption spectral changes (see the figure) and a 5 % or greater change in at least one minima or maxima of the circular dichroism spectra of the proteins.

L'invention concerne des procédés pour le dépliement des protéines au moyen de complexes métalliques, en particulier des composés du type base de Schiff renfermant du cobalt. Les protéines peuvent être des protéines virales ou de la myoglobine, et le dépliement peut être iréversible dans des conditions physiologiques. Les protéines dépliées présentent des modifications spectrales dans l'absorption des rayons ultraviolets/de la région visible du spectre (voir la figure) et une modification égale ou supérieure à 5 % dans au moins un minimum ou un maximum de spectre du dichroïsme circulaire des protéines.

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