Methods of use of thrombin receptor antagonists

A - Human Necessities – 61 – K

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Details

A61K 31/4525 (2006.01) A61K 31/343 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2545060

A method of treating a therapeutic condition comprising administering to a mammal in need of such treatment an effective amount of at least one compound of the formulas (I) and (II) or a pharmaceutically acceptable isomer, salt, solvate or co-crystal form thereof, wherein the substituents are as defined in the specification, wherein said therapeutic condition is a cardiovascular or circulatory disease or condition, an inflammatory disease or condition, a respiratory tract or disease or condition, cancer, acute renal failure, astrogliosis, a fibrotic disorder of the liver, kidney, lung or intestinal tract, Alzheimer~s disease, diabetes, diabetic neuropathy, rheumatoid arthritis, neurodegenerative disease, neurotoxic disease, systemic lupus erythematosus, multiple sclerosis, osteoporosis, glaucoma, macular degeneration, psoriasis, radiation fibrosis, endothelial dysfunction, a wound or a spinal cord injury, or a symptom or result thereof. Combination therapy with other therapeutically effective agents is also disclosed.

Méthode de traitement d'une pathologie qui consiste à administrer à un mammifère nécessitant un tel traitement une quantité efficace d'au moins un composé des formules (I) et (II) ou un isomère, sel, solvate ou co-cristal pharmaceutiquement acceptable desdits composés, les substituants étant tels que définis dans le descriptif. Ladite pathologie est une maladie ou un état pathologique cardio-vasculaire ou circulatoire, une maladie ou un état pathologique inflammatoire, une maladie ou un état pathologique des voies respiratoires, le cancer, l'insuffisance rénale aiguë, l'astrogliose, une pathologie fibreuse du foie, des reins, des poumons ou du tractus intestinal, la maladie d'Alzheimer, le diabète, la neuropathie diabétique, l'arthrite rhumatoïde, les maladies neurodégénératives, les maladies neurotoxiques, le lupus érythémateux systémique, la sclérose en plaques, l'ostéoporose, le glaucome, la dégénérescence maculaire, le psoriasis, la fibrose due aux rayonnements, le dysfonctionnement endothélial, une plaie ou une lésion de la moelle épinière, ou un symptôme ou résultat desdites pathologies. Une thérapie combinatoire avec d'autres agents thérapeutiquement efficaces est également décrite.

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