Methods to identify .beta.-amyloid reducing agents

Details Methods to identify .beta.-amyloid reducing agents Methods to identify .beta.-amyloid reducing agents

G - Physics

01

N

G01N 33/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2284261

The present invention provides methods that can be used to identify .beta.- amyloid reducing compounds. The present invention is based on the use of organotypic brain slice culturing methods to simultaneously access to toxicity and .beta.-amyloid reducing activity of a test compound.

La présente invention concerne des procédés pouvant être utilisés pour identifier des composés réducteurs de la bêta-amyloïde. La présente invention se base sur l'utilisation de procédés de mise en culture organotypique d'une structure cérébrale, qui permettent d'évaluer simultanément la toxicité et l'activité réductrice de la bêta-amyloïde d'un composé d'essai.

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