C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) G01N 33/92 (2006.01) C07J 9/00 (2006.01)
Patent
CA 2618990
As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cholesterol oxidation or ozonation products that can act as chemotactic attractants of macrophages, can promote differentiation of monocytes into macrophages and can increase expression of E-selectin and Class A scavenger receptor (SR-A). The present application is directed to methods of using such cholesterol ozonoation products to identify agents that can be used to treat atherosclerosis and other inflammatory artery diseases.
L'invention démontre que le cholestérol est oxydé pendant qu'il est présent dans des plaques d'athérosclérose. Cette réaction génère des produits d'oxydation ou d'ozonation du cholestérol pouvant exercer une attraction chimiotactique de macrophages, favoriser la différenciation de monocytes en macrophages et augmenter l'expression du récepteur SR-A et du récepteur de E-sélectine. L'invention concerne des méthodes visant à utiliser ces produits d'ozonation du cholestérol afin d'identifier des agents pouvant servir à traiter l'athérosclérose ou d'autres maladies artérielles inflammatoires.
Mbm Intellectual Property Law Llp
The Scripps Research Institute
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