C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/89, 195/128.
C12P 21/04 (2006.01) C07K 7/64 (2006.01) C12N 1/14 (2006.01)
Patent
CA 2006144
The invention relates to a microbial process for the production of immunosuppressive cyclosporine anti- biotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermenta- tion of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utiliz- able carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably Tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25 to 30 °C, and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.
Albrecht Karoly
Ambrus Gabor
Andor Attila
Buzasi Karoly
Deli Nee Konszky Etelka
Albrecht Karoly
Ambrus Gabor
Andor Attila
Buzasi Karoly
Deli Nee Konszky Etelka
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