Microcrystals of...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 473/06 (2006.01) A61K 31/522 (2006.01) A61P 11/06 (2006.01) A61P 19/10 (2006.01) A61P 25/16 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2525037

Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3- diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 µm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7- dihydro-1H-purine-2,6-dione having an average particle size of less than 50 µm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

L'invention concerne un microcristal de (E)-8-(3,4-diméthoxystyryl)-1,3-diéthyl-7-méthyl-3,7-dihydro-1H-purine-2,6-dione ayant un diamètre moyen des particules de moins de 50 µm, un microcristal de (E)-8-(3,4-diméthoxystyryl)-1,3-diéthyl-7-méthyl-3,7-dihydro-1H-purine-2,6-dione ayant un diamètre moyen des particules de moins de 50 µm et un degré de cristallinité d'au moins 20 %, etc., très soluble, stable, biodisponible et pouvant être dispersé dans des préparations médicinales. L'invention concerne également des préparations médicinales solides contenant ces microcristaux.

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