C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/06 (2006.01) A61K 31/522 (2006.01) A61P 11/06 (2006.01) A61P 19/10 (2006.01) A61P 25/16 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2525037
Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3- diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 µm; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7- dihydro-1H-purine-2,6-dione having an average particle size of less than 50 µm and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.
L'invention concerne un microcristal de (E)-8-(3,4-diméthoxystyryl)-1,3-diéthyl-7-méthyl-3,7-dihydro-1H-purine-2,6-dione ayant un diamètre moyen des particules de moins de 50 µm, un microcristal de (E)-8-(3,4-diméthoxystyryl)-1,3-diéthyl-7-méthyl-3,7-dihydro-1H-purine-2,6-dione ayant un diamètre moyen des particules de moins de 50 µm et un degré de cristallinité d'au moins 20 %, etc., très soluble, stable, biodisponible et pouvant être dispersé dans des préparations médicinales. L'invention concerne également des préparations médicinales solides contenant ces microcristaux.
Aoki Noboru
Asanome Kazuki
Hayakawa Eiji
Ishikawa Yasuhiro
Kigoshi Makoto
Goudreau Gage Dubuc
Kyowa Hakko Kirin Co. Ltd.
Kyowa Hakko Kogyo Co. Ltd.
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