C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) C12N 5/10 (2006.01) C12N 5/14 (2006.01) C12N 5/16 (2006.01) C12N 15/82 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2583690
The invention provides methods and compositions useful in target sequence suppression, target sequence validation and target sequence down regulation. The invention provides polynucleotide constructs useful for gene silencing or RNA down regulation, as well as cells, plants and seeds comprising the polynucleotides. The invention also provides a method for using microRNA to silence a target sequence or to down regulate RNA.
L'invention concerne des méthodes et des compositions utiles pour la suppression de séquences cibles, pour la validation de séquences cibles et pour la régulation négative de séquences cibles. L'invention concerne des constructions polynucléotidiques utiles pour le silençage génique ou pour la régulation négative d'ARN, ainsi que des cellules, des plantes et des semences comprenant lesdits polynucléotides. L'invention concerne en outre une méthode d'utilisation de micro-ARN pour le silençage d'une séquence cible ou pour la régulation négative d'ARN.
Chua Nam-Hai
Lin Shih-Shun
Niu Qi-Wen
Soyano Takashi
Toboda Jose Reyes
Osler Hoskin & Harcourt Llp
The Rockefeller University
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