Microsomal triglyceride transfer protein inhibitors

Details Microsomal triglyceride transfer protein inhibitors Microsomal triglyceride transfer protein inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07C 237/52 (2006.01) C07C 323/42 (2006.01) C07C 323/60 (2006.01) C07D 207/34 (2006.01) C07D 209/08 (2006.01) C07D 213/76 (2006.01)

Patent

CA 2505604

The present invention provides inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion having Formula (I) which are useful for the treatment of obesity and related diseases, as well as prevention and treatment of atherosclerosis and its clinical sequelae, for lowering serum lipids, and in the prevention and treatment of related diseases. The invention further relates to pharmaceutical compositions comprising the compounds of the present invention and to methods of treating obesity, atherosclerosis, and related diseases and/or conditions with the compounds of the present invention, either alone or in combination with other medicaments, including lipid-lowering agents.

La présente invention concerne des inhibiteurs de la protéine microsomale de transfert de triglycéride et/ou de sécrétion d'apolipoprotéine B (Apo B) de formule (I) qui sont utilisés dans le traitement de l'obésité et de maladies associées, ainsi que dans la prévention et le traitement de l'athérosclérose et de ses séquelles cliniques afin de diminuer les lipides du sérum, et dans la prévention et le traitement de maladies liées. Cette invention a également trait à des compositions pharmaceutiques qui renferment les composés susmentionnés et à des méthodes de traitement de l'obésité, de l'athérosclérose, et de maladies et/ou de troubles liés au moyen des composés de cette invention, qui sont utilisés seuls ou avec d'autres médicaments, y compris des hypolipidémiants.

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