Mif adsorbant

B - Operations – Transporting – 01 – J

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Details

B01J 20/32 (2006.01) A61M 1/34 (2006.01) A61M 1/36 (2006.01)

Patent

CA 2568694

The present invention concerns an apheresis material or adsorbant and a method for removing, depleting or inactivating MIF (macrophage migration inhibitory factor) from blood, blood plasma, blood serum or other body fluids. The present invention is also concerned with the use of said apheresis material or adsorbant. In order to prepare a novel means and novel method, which can reduce the activity or amount of the mediator for sepsis and septic shock, MIF, in a patient's body fluid in a manner which is more pleasant and tolerable for the patient than prior art means and methods, the invention proposes that the apheresis material or adsorbant comprises a solid carrier material on the surface of which MIF-binding molecules or functional groups are immobilized. The method proposes that the apheresis material or adsorbant be brought into contact extracorporeally with the blood, blood plasma, blood serum or other body fluids.

La présente invention concerne une matière d'aphérèse ou un adsorbant et une méthode destinée à enlever, réduire ou inactiver le MIF (facteur inhibiteur de la migration des macrophages) à partir du sang, du plasma sanguin, du sérum sanguin ou d'autres liquides corporels. La présente invention concerne également l'utilisation de cette matière d'aphérèse ou de cet adsorbant. Elle vise à obtenir de nouveaux moyens et une nouvelle méthode permettant de réduire l'activité ou la quantité du médiateur pour la sepsie et le choc septique, soit MIF, dans le liquide corporel d'un patient de manière plus agréable et tolérable pour le patient par rapport aux techniques et méthodes antérieures, et se caractérise en ce que la matière d'aphérèse ou l'adsorbant comprend une matière de support solide dont la surface comporte des molécules se liant à MIF ou des groupes fonctionnels immobilisé(e)s. La méthode consiste à mettre la matière d'aphérèse ou l'adsorbant en contact extracorporel avec le sang, le plasma sanguin, le sérum sanguin ou d'autres liquides corporels.

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