C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2255579
Compositions and methods are provided for the treatment of conditions associated with mitogen-activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit signal transduction via the p38-2 kinase cascade. The polypeptides and agents may be used in a variety of methods, such as in the reduction of pain sensations.
L'invention concerne des compositions et des procédés permettant de traiter des maladies associées aux cascades de protéine kinase activée par mitogène. L'invention décrit en particulier la protéine kinase p38-2 activée par mitogène et des variantes polypeptides de ladite protéine qui stimulent la phosphorylation et l'activation de substrats tels que l'ATF2. Les polypeptides peuvent être utilisés, par exemple, pour identifier des anticorps ou d'autres agents qui inhibent la transduction de signal via la cascade de la kinase p38-2. Les polypeptides et les agents peuvent être utilisés dans une variété de procédés comme, par exemple, pour réduire la sensibilité à la douleur.
Barbosa Miguel S.
Belardetti Francesco
Cobb Melanie
Stein Bernd
Wilk-Blaszczak M. A.
Gowling Lafleur Henderson Llp
Signal Pharmaceuticals Inc.
University Of Texas Southwestern Medical Center
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