C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/40 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) A61P 43/00 (2006.01) C07D 207/02 (2006.01) C07D 207/20 (2006.01) C07D 265/30 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D
Patent
CA 2487489
The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention concerne des composés dihydropyrrolés convenant, d'une part pour le traitement de troubles à prolifération cellulaire, d'utre part pour le traitement de troubles liés à l'activité de la kinésine KSP, et enfin pour l'inhibition de la kinésine KSP. L'invention concerne également, non seulement des compositions à base de ces composés, mais aussi des thérapies anticancéreuses des mammifères à base de ces compositions.
Arrington Kenneth L.
Coleman Paul J.
Cox Christopher D.
Fraley Mark E.
Garbaccio Robert M.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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