Mixed lipid-bicarbonate colloidal particles for delivering...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/107 (2006.01) A23L 1/30 (2006.01) A61K 31/14 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2222161

A composition of mixed lipid colloidal particles is disclosed containing nonesterified fatty acids having 8-24 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid, monoglycerides which are monoesters of glycerol and fatty acids having 8-24 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid, lysophosphatidylcholine in which the fatty acid moiety has 8-24 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid and a titrating agent. The compositions can optionally also contain bile salts and/or other biologically compatible surfactants. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable and sustained absorption of fats, sources of readily absorbable polyunsaturated fat and/or choline, and as particles for topical application to the skin. Methods of making these particles are also described. Also disclosed are the use of the compositions in the manufacture of medicamenets and the use of the compositions for the delivery of choline (and fats).

La présente invention concerne une composition de particules colloïdales de lipides mélangés contenant des acides gras non estérifiés portant de 8 à 24 atomes de carbone, l'acide gras étant saturé, insaturé et polyinsaturé, des monoglycérides en l'occurrence des monoesters de glycérol et des acides gras portant de 8 à 24 atomes de carbone, un tel acide gras étant saturé, insaturé et polyinsaturé, de la phosphatidylcholine dans laquelle la fraction acide gras porte de 8 à 24 atomes de carbone, l'acide gras étant saturé, insaturé et polyinsaturé, et un agent de titrage. Ces compositions peuvent éventuellement contenir aussi des sels biliaires et/ou d'autres agents tensioactifs biologiquement compatibles. Ces compositions constituent des particules colloïdales de taille submicronique faisant office de véhicules convenant au transport de médicaments, de sources de calories, de sources de matières grasses et/ou de choline polyinsaturées, administrées par voie orale sous forme de graisses facilement absorbables et à absorption prolongée. Ces particules conviennent également à des applications locales cutanées. L'invention concerne également l'utilisation de ces compositions dans la fabrication de médicaments et l'utilisation de ces compositions pour l'administration de choline (et de matières grasses).

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