Modified lipopolysaccharides and process of preparation

Details Modified lipopolysaccharides and process of preparation Modified lipopolysaccharides and process of preparation

C - Chemistry, Metallurgy

07

H

167/199, 260/225

C07H 13/06 (2006.01) A61K 31/715 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1317589

MODIFIED LIPOPOLYSACCHARIDES AND PROCESS OF PREPARATION ABSTRACT OF THE DISCLOSURE Modified lipopolysaccharides, particularly de-3-0-acylated monophosphoryl lipid A and de-3-0-acylated diphosphoryl lipid A, are provided by an alkaline hydrolysis under controlled conditions which removes only the -hydroxymyristic acyl residue that is ester-linked to the reducing-end glucosamine at position 3. The modified products are less endotoxic and maintain their antigenic and immuno-stimulating properties.

603907

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