Modified substrate and method for producing modified substrate

B - Operations – Transporting – 01 – D

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B01D 67/00 (2006.01) A61L 33/00 (2006.01) B01D 63/02 (2006.01) B01D 65/02 (2006.01) B01D 69/08 (2006.01) B01D 71/40 (2006.01) C08J 7/00 (2006.01) C08J 7/18 (2006.01)

Patent

CA 2496096

A modified substrate comprising a hydrophilic polymer in which the amount of soluble hydrophilic polymers contained is 15 wt.% or less and to which the sticking of human platelets amounts to 10 platelets / 4.3 x 103 µm2 or less; and a process for producing a modified substrate, comprising exposing to radiation a substrate while in contact with an aqueous solution containing a hydrophilic polymer and an antioxidant. Thus, there are provided a modified substrate having a hydrophilic polymer immobilized on a substrate surface, which modified substrate ensures high blood compatibility, and a process for producing the same.

L'invention concerne un substrat modifié comprenant un polymère hydrophile dans lequel les polymères hydrophiles solubles sont contenus en proportion inférieure ou égale à 15 % en poids, et sur lequel le nombre de plaquettes collées atteint une valeur inférieure ou égale à 10 plaquettes/4,4 x 10?3¿ µm?2¿. L'invention se rapporte en outre à un procédé destiné à produire un substrat modifié et consistant à exposer un substrat à un rayonnement pendant qu'il est en contact avec une solution aqueuse contenant un polymère hydrophile et un antioxydant. Ainsi, l'invention concerne un substrat modifié comprenant un polymère hydrophile immobilisé sur une surface du substrat, ce substrat modifié permettant d'obtenir une haute compatibilité sanguine, ainsi qu'un procédé de production dudit substrat.

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