Modified tgf-.beta. superfamily proteins

Details Modified tgf-.beta. superfamily proteins Modified tgf-.beta. superfamily proteins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C07K 14/31 (2006.01) C07K 14/33 (2006.01) C07K 14/47 (2006.01) C07K 14/495 (2006.01) C07K 14/705 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2345024

The invention provides modified TGF-.beta. family proteins having altered biological or biochemical properties, and methods for making them. Specific modified protein constructs include TGF-.beta. family member proteins that have N-terminal truncations, "latent" proteins, fusion proteins and heterodimers.

La présente invention concerne d'une part des protéines modifiées de la famille du TGF- beta présentant des propriétés biologiques ou biochimiques modifiées, et d'autre part des procédés de leur préparation. En outre, des produits de synthèse protéiques modifiés spécifiques comprennent des protéines des membres de la famille du TGf- beta présentant des troncations N-terminales, des protéines "latentes", des hétérodimères et des protéines de fusion.

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