C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2539181
Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
La présente invention concerne des composé oligomères, des compositions et des techniques permettant de moduler l'expression de eIF4E. Des composé antisens peuvent être simples brin ou double brin et sont ciblés sur un acide nucléique codant pour eIF4E. Cette invention concerne aussi des techniques d'utilisation de ces composés pour la modulation de l'expression eIF4E et pour le diagnostic et le traitement de maladies et de pathologies associées à expression de eIF4E.
Bhat Balkrishen
Dobie Kenneth W.
Freier Susan M.
Graff Jeremy R.
Konicek Bruce W.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
Isis Pharmaceuticals Inc.
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