Modulation of lmw-ptpase expression

Details Modulation of lmw-ptpase expression Modulation of lmw-ptpase expression

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61P 3/06 (2006.01) A61P 3/08 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) C07H 21/00 (2006.01) C12N 9/16 (2006.01) C12N 15/55 (2006.01)

Patent

CA 2609180

Disclosed herein are compounds, compositions and methods for modulating the expression of LMW-PTPase in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, dyslipidemia, hyperlipidemia, hypertriglyceridemia, and hyperfattyacidemia. In some embodiments, the diabetes is type II diabetes by administration of antisense compounds targeted to LMW-PTPase.

L'invention concerne des composés, des compositions et des procédés de modulation de l'expression de la LMW-PTPase dans une cellule, un tissu ou chez un animal. L'invention concerne également des procédés de validation de cible. De plus, l'invention concerne les différentes utilisations de ces composés et compositions dans la fabrication d'un médicament destiné à traiter certains troubles et maladies. Par ailleurs, l'invention concerne des procédés de prévention, d'amélioration et/ou de traitement du diabète, du type insulinorésistant et du type insulinoprive, de l'hypercholestérolémie, de l'hyperglycémie, de la dyslipidémie, de l'hyperlipidémie, de l'hypertriglycéridémie et de l'excès d'acides gras. Dans certains modes de réalisation, les diabètes traités sont de type II et sont traités par l'administration de composés antisens ciblant la LMW-PTPase.

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