Modulation of release from dry powder formulations

Details Modulation of release from dry powder formulations Modulation of release from dry powder formulations

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/72 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2438268

Particles which include a bioactive agent are prepared to have a desired matrix transition temperature. Delivery of the particles via the pulmonary system results in modulation of drug release from the particles. Sustained release and/or sustained phamacologic action of the drug can be obtained by formin particles which include a combination of phospholipids that are miscible in one another and have a high matrix transition temperature.

On prépare des particules comprenant un agent bioactif afin d'obtenir une température de transition de matrice désirée. La distribution de ces particules via le système pulmonaire produit une modulation de libération médicamenteuse à partir desdites particules. On peut obtenir une libération prolongée et/ou une action pharmacologique prolongée du médicament par formation de particules comprenant une combinaison de phospholipides miscibles dans un autre, et présentant une température de transition de matrice élevée.

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