Modulation of release from dry powder formulations

Details Modulation of release from dry powder formulations Modulation of release from dry powder formulations

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/72 (2006.01)

Patent

CA 2382821

Particles which include a bioactive agent are prepared to have a desired matrix transition temperature. Delivery of the particles via the pulmonary system results in modulation of drug release from the particles. Sustained release of the drug can be obtained by forming particles which have a high matrix transition temperature, while fast release can be obtained by forming particles which have a low matrix transition temperature. Preferred particles include one or more phospholipids.

La présente invention concerne des particules comprenant un agent bioactif, préparées pour avoir une température de transition matricielle désirée. L'administration des particules via le système pulmonaire provoque la modulation de la libération de médicament. La libération lente du médicament peut être obtenue par préparation de particules ayant une température de transition matricielle élevée, alors que la libération rapide du médicament peut être obtenue par préparation de particules ayant une température de transition matricielle basse. Les particules préférées comprennent un ou plusieurs phospholipides.

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