A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/13 (2006.01) A61K 35/14 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) C12Q 1/34 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2302838
The present invention relates to a sphingosine kinase signalling pathway via which cellular activities such as adhesion molecule expression are achieved. By regulating the expression and activity of individual components of this pathway, these cellular activities can be modulated. The present invention also contemplates a rapid, high volume assay for detecting agents exhibiting sphingosine kinase and agents that can act as agonists and antagonists of these sphingosine kinase activity.
La présente invention concerne un procédé permettant de moduler l'activité cellulaire et des agents pouvant être utilisés dans ce procédé. Plus particulièrement, la présente invention traite d'un procédé permettant de moduler l'activité des cellules endothéliales et plus particulièrement l'expression des molécules d'adhésion cellulaire. De manière encore plus spécifique, la présente invention a pour objet un procédé permettant de traiter les insuffisances coronariennes en prévenant ou en réduisant l'expression des molécules d'adhésion des cellules endothéliales.
Barter Philip
Gamble Jennifer
Pitson Stuart
Rye Kerry-Anne
Vadas Mathew
Gowling Lafleur Henderson Llp
Johnson & Johnson Pharmaceutical Research And Development Llc
Medvet Science Pty. Ltd.
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